Unfortunately not. I don't use 'real-time' and its (certainly) not for the faint of heart.

I keep DeP on for ALL programs.
Start -> Control Panel -> System -> Advance -> Performance -> Data Executions Prevention -> "Turn on DEP for all programs and services except those I select". Then restart your computer and BAM

If for some reason your Chrome browsers hangs too much (sometimes this happens) you can always switch it back anytime and again restart your computer if you switch it back.
To be honest, I don't know whom offers real time other than
Malware Fighter. I used to use it but it slowed down my computer too much to bare. Try and see. Also Malware Hunter is not too bad, but I'm not sure if they offer 'real-time' (I think you have to pay for the PRO version and I can not afford to pay). I've used the free version as well.
Free and fast scan PC for any malware and virus. Clean malware of an infected computer completely. The best malware protection for Windows 11/10.
www.iobit.com
Malware Hunter is an award-winning product that provides comprehensive protection against all types of threats, secures your data, protects your privacy and ensures your PC remains virus-free.
www.glarysoft.com
EDIT:
Ugh ... I just looked at the malware fighter website and it NOW read only supporting Vista. Dang

I don't know whom offers 'real-time' anymore?????