File in use by program called "Thumb".

File in use by program called "Thumb". Can not delete file and can not delete "Thumb"

I have a File that exists on my desktop that I can not delete. When I attempt to delete it I get the message that it is in use by another program called "Thumb". I ran a search on "Thumb" and got several in the system but I can not open them or delete them. I get the message that they are in use. How do I turn them off and delete them so I can delete the original file on my desktop?
 
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